If your open rate is very low, think about your From and Subject headers.
The message From: should clearly convey the organization who is sending the mail. Unless your name is deeply recognizable to your readers, make the From: your organization, domain, product or event name -- whatever will ring your readers' bells about why they want to read your message!
The subject line may be blah, or, even worse, make people think your message is spam. If your Subject is a throwaway, tacked on at the end, rather than the hook that draws people in, even the greatest content won't matter.
Also, more and more email displays the first few words of your message in the subscribers' message listing. Making these elements interesting and dynamic can dramatically improve your open rates.
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